Bioengineering, and more importantly tissue engineering, is bringing the customised medicine a different outlook. The utilisation of cells and treatments has been a common method for bringing the body to repair itself, as it also occurs with blood transfusions, bone marrow transplants, and autologous implantation of chondrocytes to re-grow cartilage.Check out QC Kinetix (Austin), TX for more info.
For over 2000 clinical trials related to cell therapies, such as stem cells for ischemic heart areas, neural precursor cells for Parkinson’s disease, and oligodendrocytes arising from embryonic stem cells to repair spinal cord injury, these procedures prepared the path.
The secret to performance is finding the right pathway for certain cells being transported. For example, cell-based therapy is used to treat knee osteoarthritis, where cartilage degradation and subchondral bone result in fewer fibrocartilage repair than the articular cartilage mechanical properties. Most people experience a severe degenerative joint condition, and more than 250,000 knee replacements are performed worldwide. In this situation, the injection into the problem area of a suspension of autologous cultured chondrocytes would not function successfully since the cells appear to develop fibro cartilage and lose their circular shape. The best approach to treat knee osteoarthritis is to inject the chondrocytes into the cartilaginous matrix which wears away much like the cartilage.
If the chondrocytes are enveloped in gels, this helps the cells to retain their rounded form, and it is possible to regulate the properties of the gels and make the tissue regenerate. The mesh must be compact enough to keep up the cells, and enough accessible to get water and nutrients. Likewise, the gel layer must disintegrate at the right rate, such that the secreted extracellular matrix is not confined only to the region around each chondrocyte.
The developed cartilage tissue will mimic the structural properties of the native cartilage to such a degree that the alignment of the cells and the regenerated cartilage appear like native cartilage. The cells that are enclosed in this form of matrix will move to and from the surface cartilage.
A critical problem brought up by cell-based therapy is how to make the most of the versatility of cells provided to a passive or reactive environment, where meaning exists for the cell form needed but where very little biological signals are generated to maintain normal cell activity.
At the end, bioengineers imagine a material structure in which the embedded cells release a signal such that deeper cells create cartilage-shaped bone white cells at the surface.
Regenerative therapy has many predictions:
— Effect of cell-based therapies on clinical medicine is the
— Strategies that promote the regeneration of skin, bone , cartilage, intestine, and trachea from stem cells of the bone marrow, and even regeneration of blood vessels and heart valves
-Restore activity of diverse tissues, such as the spinal cord
— Moving for the recovery of more complicated tissues and neo-organisms
-Tackling significant problems, such as defining cell origins and clinically important cell counts, incorporating new cells into established tissue matrices, and achieving tissue equivalent functional properties through extended biomaterial spectrum